Data from a recent paper from Liao et al. show that regular aspirin use on patients after CRC diagnosis had an impact on postsurgical survival only in the subgroup of patients with PIK3CA (phosphatidylinositol-4, 5-bisphosphonate 3-kinase catalytic subunit alpha gene) mutations in the tumour [41]. Here, PIK3CA is linked to colorectal carcinoma.