Authors demonstrated that the expression of EOMES (eomesodermin), a T-box transcription factor, was inversely correlated with the presence of lymph node metastasis at diagnosis and that was crucial in controlling the production of perforin by CD8+ CTLs and thus enhancing their cytotoxic activity [58, 59] (Fig. 1). The gene discussed is EOMES; the disease is metastatic malignant neoplasm in the lymph nodes.