Moreover, a recent study [78] of two SNPs in CYP1A1 m1    [MspI (rs4646903)] and CYP1A1 m2    [Ile462Val (rs1048943)] in a total of 457 Cantonese nuclear families, consisting of 2134 members, has concluded that there is no absence of any statistical significance between m1 polymorphism and susceptibility to NPC. The gene discussed is CYP1A1; the disease is nasopharyngeal carcinoma.