CYP1A1 and cancer: Moreover, in a previous study, Sam et al. [66] found that CYP1A1*1A/*2A and *2A/*2A polymorphic genotypes are associated with an enhanced risk to UADT cancers, in particular, among the habitual tobacco smokers and chewers carrying mutant genotypes in the Indian population (OR = 1.76; 95%  CI = 1.19–2.60 and OR = 2.83; 95% CI = 1.43–5.61, resp).