In contrast to Singh et al. [21], findings, Ko et al. [26] reported the presence of variant genotypes of CYP1B1*3 at a significantly higher frequency in smoking patients compared with healthy smokers, thus suggesting that genotypes of CYP1B1*3 significantly interact with smoking and likely represent a susceptibility factor in smoking related to HNSCC (OR = 4.53; 95% CI = 2.62–7.98; P < 0.001). The gene discussed is CYP1B1; the disease is head and neck squamous cell carcinoma.