Veraldi et al. [5] showed that insulin-like growth factor binding protein-3 IGFBP-3 levels are increased in bronchoalveolar lavage (BAL) fluid of asthmatic patients 48 hours after allergen challenge, suggesting that this is the most important protein that IGF binds, developing airway remodeling in asthma through this modulation. This evidence concerns the gene IGFBP3 and asthma.