Risk factors for the development of IRIS in HIV-infected individuals include antiretroviral naiveté, using a boosted protease inhibitor, low CD4 lymphocyte counts (<100 cells/mm3), higher level of viremia at baseline, rapid decrease in HIV load, rapid immune recovery following the initiation of HAART, and the presence of active or subclinical opportunistic infections at the time of initiation of HAART [8, 9]. This evidence concerns the gene CD4 and Opportunistic infection.