They also pointed out that in mouse antigen-induced arthritis (AIA) which resembles human RA, IL-33 could induce and mediate neutrophil migration by activating synoviocytes and macrophages, and this induction was dependent on CXCL1, CCL3, TNF-alpha, and IL-1beta [46]. The gene discussed is IL33; the disease is rheumatoid arthritis.