Zinc was found to inhibit cancer through regulating various oncogenic pathways including NF-κB, AP-1, Notch-1, and PI3K/Akt, apoptosis, cytotoxicity, regulating tumor suppressors such as p53 and macrophage phagocytic activities and increased production of ROS and inflammatory cytokines TNF-α, IL-1β, IL-8, VCAM, and MCP-1 [112]. This evidence concerns the gene NFKB1 and cancer.