CXCL10 and Hand-foot syndrome: Immune privilege is the most intriguing feature of HF immunology that is characterized by the downregulation of MHC class I. The collapse of HFIP is induced by certain environmental factors such as virus infections, and it involves the production of the Th1/Tc1 chemokine, CXCL10, in HFs that attracts Th1 and Tc1 cells towards the hair bulbs.