At p3, the morphology of BM-MSCs from SLE patients culture in p21 siRNA appeared a fibroblast-like morphology (Figure 6(a)); moreover, cell proliferation assay showed that the proliferation rate of p21 knockdown BM-MSCs from SLE patients was increased (Figure 6(b)) and CFU potential of BM-MSCs from SLE patients cultured with p21 siRNA increased by about a half (Figures 6(c)-6(d), P < 0.05). The gene discussed is CDKN1A; the disease is systemic lupus erythematosus.