To conclude, utilizing powers of HAART, either by developing compounds or bio-molecules to stop provirus transcription or reprograming memory CD4 T-cells to reconstitute patient HIV-specific immunity, we can pave a road for generating effective AIDS vaccines; by deciphering the mechanisms of memory CD4 T-cell guided immunity, we may open a door reconstituting patient immunity against not only cancer but AIDS. This evidence concerns the gene CD4 and AIDS.