Considering the double role of memory CD4 T-cells in HIV immunity and infection, we believe utilizing epigenetic regulation to silence HIV in memory CD4 T-cells is a win–win strategy, which silences HIV without hurting cellular gene expression, and stops HIV provirus without losing lives of memory CD4 T-cells who intend to be long-memory, long-living, and everlasting to patient HIV-specific immunity. Here, CD4 is linked to infection.