A trinity of strategies on HIV/AIDS eradication and cure stems from the three theories or three scientific achievements: (1) defining CD4 T-cells in HIV/AIDS pathogenesis and immunity, (2) developing highly active anti-retroviral therapy to stop HIV replication; and (3) studying of ancient human endogenous retroviruses (HERVs) in the human genome, of which HIV is a modern example. The gene discussed is CD4; the disease is AIDS.