This likely reflects the multitude of suppressive mechanisms that nTreg are able to utilize to mediate suppression, as tumor-infiltrating Ebi3−/− nTreg were able to suppression T-cell proliferation at equal levels compared with wild-type nTreg (22), and even Treg that lack both IL-35 and IL-10 expression can still mediate suppression through factors such as TRAIL (56). The gene discussed is EBI3; the disease is neoplasm.