Although the role of the RAS concerning invasion of trophoblast and placentation is poorly investigated, there is evidence that dysfunction of this system may cause hypertension and preeclampsia (56, 72, 73, 74): patients with preeclampsia present with increased expression of Angiotensin II and AT1R in maternal decidua cells and in the placenta itself (74, 75). Here, AGTR1 is linked to preeclampsia.