Furthermore, besides presence of Angiotensin II and Angiotensin (1–7), expression of AT1R, AT2R, and Mas-receptor human reproductive tissue is needed in order to mediate the local impact of the RAS for physiological and pathological processes, including follicle maturation, fine-tuning of the regulation of reproduction, angiogenesis as well as tumor cell proliferation (15–18). Here, AGTR1 is linked to neoplasm.