Overall, it appears that tau may be secreted via multiple mechanisms from neurons in tauopathy, including microvesicle shedding, exosomal secretion via endocytosis and fusion with multivesicular bodies, and exophagy, a pathway involving the diversion of autophagosomes to exosomes (69, 81, 134, 207). The gene discussed is MAPT; the disease is tauopathy.