PRNP and frontotemporal dementia: Moreover, conditions in which SNCA (Parkinson’s disease, Lewy Body Dementia), tau (Corticobasal Degeneration, Pick’s disease, Frontotemporal Dementia), and PrP [Creutzfeldt–Jakob disease (CJD), Gerstmann–Straussler–Scheinker disease] form abnormal aggregates typically show overlapping neuropathology, suggesting that synergistic interactions may occur between these proteins in each of these conditions (7).