Further studies using antibodies specific to oligomerized tau have demonstrated that pre-fibrillar tau in AD brain is in fact oligomeric (208) and that tau oligomers derived from the brains of AD patients can recruit endogenous tau to oligomers both in vitro (97) and in vivo (96) and that intracerebral injection of oligomeric but not fibrillar wild-type tau caused aggregate formation from endogenous tau in synaptically connected but distant areas (96). The gene discussed is MAPT; the disease is Alzheimer disease.