Studies in cellular tauopathy models showing a correlation between localized cytotoxicity, tau membrane association, and localized MT loss (81, 130, 165) are consistent with this (see examples in Figure 2), as is the presence at the plasma membrane of polyanionic molecules known to catalyze tau oligomer/filament formation such as HSPGs (30, 166) and RNA (123). The gene discussed is MAPT; the disease is tauopathy.