MAPT and tauopathy: The ability of tau filaments to form in vitro by MT-templated mechanisms (119), and the ability of tauopathy mutations to actively disrupt MT networks (116) as well as favor filament formation (117, 120) are all consistent with the idea that tau aggregate formation, eventually leading to NFTs, begins immediately upon dissociation from MTs or even by conformational changes that occur in MT-bound tau.