However, in light of the studies, by our and other groups, finding that PP2A activity is stimulated by nutrients to promote glycogen- and lipid storage through acting on key enzymes and transcription factors such as GS, phosphorylase, ACC, AMPK and ChREBP we propose a model where the role of PP2A hyperactivity in states of overnutrition represents a normophysiological adaptation to promote energy storage (Figure S7). The gene discussed is PTPA; the disease is overnutrition.