ITGAX and obesity due to melanocortin 4 receptor deficiency: Infiltration of monocytes is enhanced in obesity via local tissue cues, with a progressive transformation of these cells to a CD11c+ status, resulting in a polarization of the local adipose milieu to an M1 state from a predominantly M2 state under conditions of normal diet (Lumeng et al. 2007b; Oh et al. 2012).