By contrast, RRAS1 mRNA expression was enhanced in CNS tumors, albeit not to the same extent as RRAS2. Given that unlike RRAS1 or RRAS3, RRAS2 can transform NIH-3 T3 cells [8-11], and in light of the low frequency of oncogenic mutations in classic Ras genes, we hypothesize that R-RAS2 overexpression is an important event in the transformation of neural cells, particularly those that do not carry oncogenic RAS mutations (database reference). Here, RRAS is linked to central nervous system neoplasm.