As the knockdown of MDM2 in p53 mutant non-small cell lung cancer [35,36], the FASN reduced expression in HepG2 cells [37,38] or the SOD1 downregulation in AMLs [39,40] can induce apoptosis, we might suggest a HOXB1 related anticancer activity. The gene discussed is SOD1; the disease is non-small cell lung carcinoma.