Several other genes in the top 10 upregulated probesets are also overexpressed in tumours including PCP4 in leiomyomas (22), HOXC6 in oesophageal (30), breast (31) and lung carcinomas (32) and IL16RA2 in glioblastomas (33), prostate cancer and adrenocortical tumours (34). The gene discussed is HOXC6; the disease is lung carcinoma.