Alterations in the levels of the insulin-like growth factor-binding proteins (IGFBPs) have been identified in 3-M syndrome patient cell lines, both at the RNA level for IGFBP2 and 5 (14) and at the protein level for IGFBP2, 5 and 7 (13). Here, IGFBP2 is linked to multiple congenital anomalies-hypotonia-seizures syndrome 3.