More recent data on mouse indicate that the overgrowth of Gpc3 null mice is independent of IGF-II (38), while data on the role of GPC3 in the growth of cancer cell lines are inconsistent with some studies suggesting that GPC3 suppressed growth in an IGF-dependant manner (39) while others identified GPC3 as a growth-promoting protein (40, 41). This evidence concerns the gene IGF2 and cancer.