Recently, some independent genome-wide association studies have identified that several genetic polymorphisms of the IL28B gene (also known as IFN-λ3), such as rs8099917 and rs12979860, effectively predicts responses in patients with chronic hepatitis C infections treated with PEG-IFN-α/RBV[15-17]. This evidence concerns the gene IFNL3 and chronic hepatitis C virus infection.