IFNG and infection: IFN-γ is known to mediate several immune responses including activation of macrophages and neutrophils, enhancement of the NK cell activity, regulation of B cell functions, stimulation of specific cytotoxic T cell immunity, chemokine gene expression, increase in expression of MHC class I and II proteins, leukocyte attraction to the site of infection as well as contributing to the growth, maturation and differentiation of many cell types [26][44][45][46][47].