The diagnostic accuracy of GCglycoB in differentiating GC from atrophic gastritis increased 21.26%, 24.64%, 31.40% and 34.30% and the sensitivity increased 27.97%, 35.59%, 55.09% and 60.17% compared with CEA, CA19-9, CA125 and CA72-4, respectively (Table 7). Here, CEACAM5 is linked to chronic atrophic gastritis.