While our whole genome sequencing did not detect any small variant mutation, structure analysis identified a focal hemizygous deletion of 16 Kb involving exons 10-12 in the ATRX gene in Met2 as shown in a coverage plot at the base-pair level (Figure 2A) and indicated by detection of an abnormal junction in the tumor DNA (Table S3). The gene discussed is ATRX; the disease is neoplasm.