The IL-13RA2 receptor belongs to a tri-molecular signature of human GBM also including the EphA2 receptor and a transcription factor Fra-1 (19), and recent studies are suggestive of IL-13RA2 and EphA2 belonging to a group of factors characterizing glioma stem-like cells [38-40]. This evidence concerns the gene IL13RA2 and glioma.