The levels of NPC2 in groups with healthy control, chronic HBV infection, chronic HCV infection, fatty liver, cirrhosis and HCC were 3.29 ± 1.43 ng/ml, 4.51 ± 1.88 ng/ml, 9.66 ng/ml (maximum value, 15.81 and minimum value, 3.504), 7.49 ± 2.30 ng/ml, 15.30 ± 2.02 ng/ml and 7.26 ± 2.11 ng/ml, respectively. The gene discussed is NPC2; the disease is hepatocellular carcinoma.