We have successfully employed this approach to identify ATP1A1 (α1 Na,K-ATPase) [10,11] and DEspR (dual endothelin1/vascular endothelial growth factor signal peptide receptor) [12,13] as candidate hypertension genes in a Dahl salt-sensitive rat model of polygenic hypertension. The gene discussed is ATP1A1; the disease is hypertensive disorder.