FOXO3 and gastric cancer: Further, we analyzed the FOXO3 firefly luciferase reporter activity (a negative indicator of RAS/PI3K/AKT pathway activation) in the same gastric cancer cell lines and identified FOXO3 reporter activity to be higher in wild type cells (Kato III) while compared to KRAS mutant cell lines (AGS and YCC16) (Figure 4F).