Systematic analysis of EXO1 expression across these breast cancer profiles revealed consistent elevated expression of EXO1 in i) breast tumors when compared to normal breast tissues (Figure S1A), ii) higher grade breast tumors (Figure 2D), iii) ER negative while compared to ER positive tumors (Figure 2E), iv) PR negative subtype of breast tumors (Figure S1B), and v) basal subtype breast tumors when compared to luminal subtypes (Figure S2). Here, ESR1 is linked to breast cancer.