Hierarchical clustering (Figure 3A and Figure S3A), regression analysis (Table S5-S6) and principal component analysis (Figure 3B and Figure S3B) of signature based activation pattern of pathways revealed a significant positive association of EXO1 gene expression with the activation of MYC, RAS, EGFR, Genomic instability, and E2F pathways in breast tumors and cell lines. The gene discussed is MYC; the disease is breast neoplasm.