A significant proportion of the combined cohort (n = 10; healthy control + MS) decreased relative expression of Hap4 in response to IFNβ when the 3 cell subsets (mono, iDC, mDC) were included in the analysis (p = 0.043, sign test); this did not reach significance for individual groups or cell subsets, The trend was the same in MS and controls. The gene discussed is IFNB1; the disease is myeloid sarcoma.