Previous studies have suggested AI to be associated with the Cardiometabolic Syndrome: AI patients are insulin resistant with higher post-glucose-load plasma glucose concentrations and therefore increased prevalence of type-2 diabetes mellitus (T2DM) or glucose intolerance, as well as arterial hypertension and dyslipidaemia, all of which may contribute to the observed, greater cardiovascular risk [3-9]. The gene discussed is INS; the disease is diabetes mellitus.