Five human NSCLC cell lines, with known EGFR, K-ras, B-raf, PI3K, LKB1 and TUSC2 (shown as 3p abnormalities) gene status, were evaluated for sensitivity to MK2206 after TUSC2 transfection (Table 1). The gene discussed is TUSC2; the disease is non-small cell lung carcinoma.