KMT5A and diabetes mellitus: As shown in Table 3, the protective effect of variant genotypes of SET8 rs16917496 were more prominent in never smokers (adjusted HR = 0.54, 95% CI: 0.35–0.83), patients without diabetes (adjusted HR = 0.70, 95% CI: 0.53–0.94), patients who received chemotherapy (adjusted HR = 0.69, 95% CI: 0.51–0.92) but not targeted therapy (adjusted HR = 0.52, 95% CI: 0.24–1.02).