CYP2E1 and metabolic dysfunction-associated steatohepatitis: In Cyp2e1 null-mice, increased expression of CYP4A has been observed during lipid accumulation in nonalcoholic fatty liver (NAFLD) and steatohepatitis (NASH) caused by high fat diets (HFD) [41] or methione-choline-deficient diet [42].