The analysis between pro-inflammatory cytokines, IL-8, and CRP in IC/BPS serum samples, showed significant association between IL-1β and IL-8 (Fig. 2A, r2 = 0.54, p<0.001), IL-6 and CRP (Fig. 2B, r2 = 0.17, p = 0.01), IL-6 and IL-8 (r2 = 0.17, p = 0.02), and IL-6 and TNF-α (r2 = 0.16, p = 0.03). This evidence concerns the gene CRP and Bartsocas-Papas syndrome 1.