NDRG2 and cancer: The N-myc downstream regulate gene 2 (NDRG2) belongs to the NDRG family, which includes four members: NDRG1, NDRG2, NDRG3 and NDRG4. The sequence homology within the human NDRG family is 57-65% and the NDRG family has been investigated in some of human cancer and nervous system disorders [4].