In this study, western blot assay showed that LEN-NDRG2 in T24 cells was associated with significant reduction in MMP-9 expression and slightly reduced MMP-2 expression suggesting that NDRG2-overexpression may regulate the expression of MMP-2 and MMP-9 and inhibit the invasion ability of metastatic bladder cancer cells. The gene discussed is MMP2; the disease is urinary bladder carcinoma.