Interestingly, our DCgenes list covered considerable relevant genes, including IL8, IL1B, TNF, CCL2, CCL5, CCL8, CCL3, CXCL1, CXCL5, CCL7, CCL4, CCR5, and CCR10 (Table 3 and Figure 3), and thereby offered independent evidence to reinforce the link between cytokine network and dental caries. Here, CCL4 is linked to dental caries.