CDKN2A and ductal breast carcinoma in situ: Table 3 depicts the remainder of these findings. In this way, aberrant overexpression of p53 was found to be related to high p16 expression in DCIS and IDC triple-negative subtypes (P<0.007). Because as p53 mutation is closely correlated with aberrant overexpression of p53 [29]–[31], these results might indicate that the dysfunction of the p53 pathway chiefly occurs in triple-negative breast cancers.