Among all tested cytokines TNF was the most potent: apart from irresponsive IMACs of control patients all cell types increased the synthesis of gp96 mRNA between 3.5- (i.v.DCs) and 2-fold (i.v.MACs and IMACs from IBD patients), respectively, while IFN-γ was able to induce higher levels only in i.v.DCs (2-fold). This evidence concerns the gene IFNG and inflammatory bowel disease.