Small RNA sequencing of these two fractions revealed that, although miR-4772-5p-iso is expressed at high abundance in CD14 depleted PBMCs (Figure 4 A), expression in CD14+ monocytes generated more than a 4 fold change between sepsis and SIRS patient groups whereas only less than 2 fold change was observed in CD14 depleted population (Figure 4 B). The gene discussed is CD14; the disease is systemic inflammatory response syndrome.