CYP3A4 and metastatic neoplasm: It should be noted that the gene GSTP1 was in an association with ferritin H gene [50], gene LHB was significantly with testosterone and estradiol levels [51] and special CYP3A/KLK3 genotypes increased metastatic disease while the expression of CYP3A in prostate cancer was regulated by androgen [52], [53].