For LEP, there are two SNPs that reportedly change amino acid of the protein but only G2548A (rs7799039) was extensively investigated for its association with cancer risk; for LEPR, there are five common (minor allele frequency > 0.05) SNPs that may cause amino acid changes, but only Q223R (rs1137101) was studied for its association with cancer susceptibility. The gene discussed is LEPR; the disease is cancer.