Retrospective analysis of five different studies that had as main objective the correction of anemia, showed that injection of epoetin reduce hepcidin expression and facilitates intestinal absorption of iron, approximately 35-40% of cancer patients are resistant to treatment with epoetin, patients low baseline hepcidin responded better to treatment with epoetin, at higher values of initial hepcidin the number of non-responders is higher. This evidence concerns the gene EPO and anemia.