The possibility of hepcidin use in assessing the response to existing therapies in neoplastic disease and the therapeutic intervention over hepcidin represents a current research topic.Data concerning the physiopathology of iron circuit in the bodyThe analysis of data regarding the role of hepcidin in neoplastic pathology first requires a synoptic overview of the factors influencing the iron circuit in the body [3-10] (Fig. 1). Here, HAMP is linked to neoplasm.