Acknowledgements: This articles is part of a larger national grant – PNCD I research Project no 041-087/2007: "Molecular monitoring of hybrid BCR-ABL oncogene in chronic myelogenous leukemia (CML) through cantitative real time PCR: foundation of national registry for CML patients" (2007 – 2010). The gene discussed is BCR; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.