AKR1C4 and colorectal carcinoma: In total, we identified 11 candidate predisposing genes with 14 truncating germline variants in at least two familial CRC cases (Table 2); UACA, SFXN4, TWSG1, PSPH, NUDT7, ZNF490, PRSS37, CCDC18, PRADC1, MRPL3, and AKR1C4. A summary of all these variants and respective frequencies are presented in Table 2.