In total, we identified 11 novel candidate CRC susceptibility genes with rare truncating variants in two or three familial CRC cases; UACA, SFXN4, TWSG1, PSPH, NUDT7, ZNF490, PRSS37, CCDC18, PRADC1, MRPL3, and AKR1C4 (Table 2 and Table S2). Here, AKR1C4 is linked to colorectal carcinoma.