The last example of a multi-target profile of potential relevance to malaria (Figure 6C) contains the three cysteine proteases falcipain 2a (FP2A, PF11_0165), 2b (FP2B, PF11_0161) and 3 (FP3, PF11_0162), all belonging to the high-priority subset, two targets biased towards higher affinity values for active compounds, namely, the heat shock protein Hsp90 (PF07_0029) and the Rab GTPase Rab2 (PFL1500w), and mannose-6-phosphate isomerase (MPI, MAL8P1.156). Here, CTSB is linked to malaria.