The hMSH4 non-synonymous SNP G289→A (i.e., encoding hMSH4Ala97Thr) has been associated with an increased risk for breast cancer [39], while hMSH4 G1243→A (i.e., encoding hMSH4Glu415Lys) has been identified as an important marker for blood malignancy [40]. This evidence concerns the gene MSH4 and breast cancer.