MYC and B-cell non-Hodgkin lymphoma: Following this observation, it was shown that in mouse models of B-cell lymphomas the ectopic expression of miR-17-92 cooperates with the oncogenic activity of c-Myc [15,16] and that the overexpression of this cluster in mouse lymphocytes is sufficient to induce a lymphoproliferative disorder of the B and T cell compartments [17].