In vitro transfection of synthetic miR-29b mimics in MM cells promoted apoptosis and cell cycle perturbations and potentiated the growth-inhibitory effects of the DNMT inhibitor 5-azacitidine, suggesting new strategies based on the combination of DNA-demethylating agents and miRNAs in the treatment of MM [121]. The gene discussed is DNMT1; the disease is Miyoshi myopathy.