Moreover, down-regulation of E2F7 levels by miR-26a results in inhibition of c-Myc transcriptional activity, leading to the down-regulation of the c-Myc transcriptional target miR-17-92 cluster [24], whose expression has a well-defined role in contributing to block monocytic differentiation and sustain AML cell proliferation (see below). Here, E2F7 is linked to acute myeloid leukemia.