PXDN and B-cell chronic lymphocytic leukemia: Furthermore, overexpression of miR-29a in mouse mature and progenitor B-cells produced CLL, at least in part, by targeting the tumour-suppressive cell-adhesion molecule peroxidasin homologue (PXDN) [66], indicating that miR-29 can predispose cells to a cancerous state and contributes to the pathogenesis of indolent CLL [66].