PTTG1 and cancer: The aim of the present study was to analyze this region and its association with PTC in a well-selected case–control population of the Northern area of Italy, adopting, as genetic markers, the rs2910164 SNP of pre-miR-146a and, for the first time, the rs1862391 and rs2910201 SNPs of PTTG1. The latter gene was selected both for its involvement in cancers and for its genomic proximity to pre-miR-146a, making it a possible ‘true’ candidate for the genomic association with PTC previously inconsistently found with pre-miR-146a.