It has recently been shown that the genomic region on chromosome 5, encompassing pre-miR-146a and PTTG1, is associated with systemic lupus erythematosus (SLE) (12, 14) and cancers (15, 16, 17), including papillary thyroid tumor (5, 6, 7, 8, 10). The gene discussed is PTTG1; the disease is systemic lupus erythematosus.