In the light of the results of the present study, demonstrating the effects of PRKAR2B silencing in cultured cells, it appears that further studies are needed to investigate the role of PRKAR2B in adipogenesis in vivo and to determine whether a decrease in lipolysis would be sufficient to explain obesity and the possible relative involvement of adipogenesis. Here, PRKAR2B is linked to obesity due to melanocortin 4 receptor deficiency.