Further research suggested that rs944289 was located in a CEBP-alpha/CEBP-beta binding element in the 5-prime UTR of a thyroid-specific lincRNA gene, papillary thyroid carcinoma susceptibility candidate 3 (PTCSC3), PTCSC3 had the characteristics of a tumor suppressor, the rs944289 T risk allele reduced PTCSC3 promoter activation and thereby predisposes to PTC [21]. This evidence concerns the gene PTCSC3 and neoplasm.