Inaddition, we examined the disease activity using SLE disease activity index (SLEDAI) [16], anti-dsDNA antibody, IFN-γ, IL-6 and IL-10 in SLE to determine whetherapoE is involved in the pathogenesis of SLE, and the possible effects of glucocorticoidon apoE and other cytokines activities in SLE patients. The gene discussed is IL10; the disease is systemic lupus erythematosus.