We conducted this study to investigate the correlation of the total adiponectin and the HMW adiponectin levels in the serum and follicular fluid (FF) with a number of follicles and larger follicular diameters in Chinese women with PCOS compared with the age and body mass index (BMI)-matched normovulatory women who were undergoing IVF. This evidence concerns the gene ADIPOQ and polycystic ovary syndrome.