The mean HMW adiponectin values were significantly lower in the serum (2.95 ± 0.21 vs. 4.59 ± 0.39 ug/ml, P = 0.000) and FF (1.57 ± 0.13 vs. 2.68 ± 0.19 ug/ml, P = 0.002) in the women with PCOS undergoing controlled ovarian hyperstimulation. Here, ADIPOQ is linked to polycystic ovary syndrome.