As shown in Table 1, low miR-497 expression was observed to be closely correlated with higher differentiation grade, positive HER-2 expression, higher incidence of lymph node metastasis and advanced clinical stage (P = 0.005, 0.024, 0.001 and 0.010, respectively). The gene discussed is ERBB2; the disease is metastatic malignant neoplasm in the lymph nodes.