ESR1 and metastasis: As shown in Table 2, it was observed that miR-497 expression, along with age, tumor size, differentiation grade, histological type, ER status, PR status, HER status, lymph node metastasis and clinical stage, was responsible for efficacy of surgical treatment in BC patient, by indicating that status of miR-497 expression was significantly correlated with DFS (P = 0.005) and OS (P = 0.036) of BC patients.